2nd man apparently free of AIDS virus following stem cell transplant

/ AP

A London man appears to be free of the AIDS virus after a stem cell transplant, the second success including the "Berlin patient," doctors reported. The therapy had an early success with Timothy Ray Brown, a U.S. man treated in Germany who is 12 years post-transplant and still free of HIV. Until now, Brown is the only person thought to have been cured of infection with HIV, the virus that causes AIDS.

Such transplants are dangerous and have failed in other patients. They're also impractical to try to cure the millions already infected.

The latest case "shows the cure of Timothy Brown was not a fluke and can be recreated," said Dr. Keith Jerome of Fred Hutchinson Cancer Research Center in Seattle who had no role. He added that it could lead to a simpler approach that could be used more widely.

The case was published online Monday by the journal Nature and will be presented at an HIV conference in Seattle.

The patient has not been identified. He was diagnosed with HIV in 2003 and started taking drugs to control the infection in 2012. It's unclear why he waited that long. He developed Hodgkin lymphoma that year and agreed to a stem cell transplant to treat the cancer in 2016.

With the right kind of donor, his doctors figured, the London patient might get a bonus beyond treating his cancer: a possible HIV cure.

Doctors found a donor with a gene mutation that confers natural resistance to HIV. About 1 percent of people descended from northern Europeans have inherited the mutation from both parents and are immune to most HIV. The donor had this double copy of the mutation.

That was "an improbable event," said lead researcher Ravindra Gupta of University College London. "That's why this has not been observed more frequently."

The transplant changed the London patient's immune system, giving him the donor's mutation and HIV resistance.

The patient voluntarily stopped taking HIV drugs to see if the virus would come back.

Usually, HIV patients expect to stay on daily pills for life to suppress the virus. When drugs are stopped, the virus roars back, usually in two to three weeks.

That didn't happen with the London patient. There is still no trace of the virus after 18 months off the drugs.

Man "cured" of AIDS: Timothy Ray Brown 11 photos

Brown said he would like to meet the London patient and would encourage him to go public because "it's been very useful for science and for giving hope to HIV-positive people, to people living with HIV," he told The Associated Press Monday.

Stem cell transplants typically are harsh procedures which start with radiation or chemotherapy to damage the body's existing immune system and make room for a new one. There are complications too. Brown had to have a second stem cell transplant when his leukemia returned.

Compared to Brown, the London patient had a less punishing form of chemotherapy to get ready for the transplant, didn't have radiation and had only a mild reaction to the transplant.

Dr. Gero Hutter, the German doctor who treated Brown, called the new case "great news" and "one piece in the HIV cure puzzle."

Trump promises to defeat AIDS, but his record raises skepticism

First published on March 4, 2019 / 10:31 PM

© 2019 The Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed.

Man "cured" of AIDS: Timothy Ray Brown

2nd man apparently free of AIDS virus following stem cell transplant

The procedure has been called dangerous and has failed in other patients; the patient from London hasn't been identified

10M ago

Trump speaks to state attorneys general at the White House

16 states have sued the administration​ over his declaration of a national emergency along the southern border

1H ago

Stars, friends pay tribute to Luke Perry on social media

Stars filled social media with tributes following the death of actor Luke Perry on Monday following a "massive stroke" at age 52

2H ago

"Leaving Neverland": Jackson estate releases concerts while doc airs

Jackson's estate sued HBO over "Leaving Neverland," and his family has worked to discredit the documentary

2H ago

Luke Perry, "Beverly Hills, 90210" star, dies at 52

Perry died Monday after suffering a "massive" stroke last week, his rep says

2H ago

Trump speaks to state attorneys general at the White House

16 states have sued the administration​ over his declaration of a national emergency along the southern border

1H ago

12 detained babies have been released from ICE custody in Texas

ICE said there were 16 infants younger than a year old held at the South Texas Family Residential Center as of Friday

4H ago

House to vote on anti-Semitism resolution after Omar remarks

The House will vote as early as this week on a "resolution condemning anti-Semitism," according to a senior Democratic aide

7H ago

Judge won't expedite case for "ISIS bride"

Hoda Muthana left Alabama at the age of 19 to join ISIS in Syria. Now she wants to return to the U.S. with her young son

9H ago

Former Acting AG Matt Whitaker leaves Justice Department

It's unclear what the former acting attorney general will do next

9H ago

2nd man apparently free of AIDS virus following stem cell transplant

The procedure has been called dangerous and has failed in other patients; the patient from London hasn't been identified

10M ago

12 detained babies have been released from ICE custody in Texas

ICE said there were 16 infants younger than a year old held at the South Texas Family Residential Center as of Friday

4H ago

Female cyclist forced to stop after catching up to men in race

Nicole Hanselmann excelled to start the race and called it an "awkward moment" when she caught up to the men, whose race started 10 minutes earlier

6H ago

Over 1,500 turtles found stuffed in suitcases

The turtles were worth more than $86,000

11H ago

Hundreds flee last enclave, including fighters, as ISIS loses grip

As many as 700 people expected to evacuate tiny sliver of land still held by extremists in eastern Syria — but not for long, U.S. allies vow

12H ago

Stars, friends pay tribute to Luke Perry on social media

Stars filled social media with tributes following the death of actor Luke Perry on Monday following a "massive stroke" at age 52

2H ago

"Leaving Neverland": Jackson estate releases concerts while doc airs

Jackson's estate sued HBO over "Leaving Neverland," and his family has worked to discredit the documentary

2H ago

Luke Perry, "Beverly Hills, 90210" star, dies at 52

Perry died Monday after suffering a "massive" stroke last week, his rep says

2H ago

"Leaving Neverland" forces fans to question Jackson legacy

NYT writer Wesley Morris says the documentary claims the the late pop star understood he was crossing a moral barrier with two boys who, now grown, accuse him of abuse

13H ago

Keith Flint, lead singer of The Prodigy, found dead

The band, who were due to tour the U.S. in May, confirmed his death in a statement, remembering Flint as a "true pioneer, innovator and legend"

14H ago

Social media influencers may sway kids to eat more junk

"This is the modern-day version of using popular cartoon characters to sell sugary breakfast cereals or juice boxes"

5H ago

"Brotopia" author on slow progress for women in tech

Emily Chang, author of "Brotopia: Breaking up the Boys' Club of Silicon Valley," says the disparity is causing bias to be built into products

8H ago

Scientists prove bees can do math

A new study finds that honeybees can perform basic arithmetic – adding or subtracting – triggered by color cues

Mar 3

SpaceX craft pulls off flawless docking with space station

SpaceX moves a step closer to launching astronauts on its Crew Dragon spacecraft

Mar 3

SpaceX capsule for astronauts blasts off toward space station

SpaceX launches unpiloted crew ship on historic test flight

Mar 2

2nd man apparently free of AIDS virus following stem cell transplant

The procedure has been called dangerous and has failed in other patients; the patient from London hasn't been identified

10M ago

FDA could approve ketamine spray as depression treatment

The drug can only be used in a doctor's office, and is in the form of a nasal spray

4H ago

Social media influencers may sway kids to eat more junk

"This is the modern-day version of using popular cartoon characters to sell sugary breakfast cereals or juice boxes"

5H ago

OxyContin maker Purdue Pharma may declare bankruptcy

Drugmaker facing myriad lawsuits over its role in the opioid epidemic is weighing a Chapter 11 filing, Reuters reports

6H ago

Luke Perry's sudden death and the warning signs of stroke

The actor's death serves as a tragic reminder that stroke can affect anyone at any age, and the effects can be devastating

6H ago

$1.5 billion mystery solved: Mega Millions winner comes forward

An April 19 deadline was looming for the winner to come forward, before the state and convenience store that sold the ticket lost out

5H ago

After Sears, which retailers could be the next to fall?

Crippling debt could push a number of other name retail chains over the edge this year, Moody's predicts

5H ago

OxyContin maker Purdue Pharma may declare bankruptcy

Drugmaker facing myriad lawsuits over its role in the opioid epidemic is weighing a Chapter 11 filing, Reuters reports

6H ago

Virgin Atlantic drops mandatory makeup rule for female crew

The move from a major airline represents a symbolic shift in the industry, long notorious for rules about flight attendants' physical appearance

8H ago

Eli Lilly to sell half-price insulin. Diabetics say it's not enough

The move comes amid greater scrutiny over the surging cost of insulin, but diabetics say it's still too expensive

9H ago

Mother speaks after daughter's husband arrested for attack

Jacquelyn Smith's husband and stepdaughter initially claimed she was stabbed by a panhandler

3H ago

Man charged with setting fire to Planned Parenthood clinic

Wesley Brian Kaster, 42, was arrested and charged Saturday

5H ago

Disturbing allegations against suspect in mom's kidnap, killing

When Louis Coleman III was pulled over by police in Delaware, he allegedly told officers: "She's in the trunk"

5H ago

Ex charged in blast that killed California spa owner

Feds say a friend of Ildiko Krajnyak told investigators "her boyfriend was jealous, controlling, and possessive of her"

8H ago

"Disturbing" items found after Air Force major's wife disappears

Police say Andre McDonald is charged with evidence tampering and refused to help investigators find his missing wife

11H ago

LEAVE A REPLY

Please enter your comment!
Please enter your name here